Tyrosinase, which is responsible for pigmentation, remains “metabolically” inactive (alpha-MSH antagonist and pigment accumulation modulator)
The complexion is enhanced with a radiant glow and the signs of age are smoothed out, after 2 months of treatment
Super-fast lightening effect (7 days) by combining AHAs
Specificities:
2 in vivo tests
ECOCERT certified
Preservative-free
Defined molecule
Powder
Applications:
Radiant complexion
Anti-senescence spots
Lightening skincare
Transparent lotion
Sepiwhite™ MSH is a lipoaminoacid or vectorized essential amino acid developed from phenylalanine, an amino acid involved in melanin synthesis. MSH is an alpha-melanocyte-stimulating hormone (MSH) receptor agonist developed from this amino acid that inhibits the process of melanin synthesis from the hypothalamus to produce a reduction in melanic pigments in skin cells.
In two studies, 1% Sepiwhite™ MSH was combined with 5% niacinamide in lotion. Volunteers reported a reduction in hyperpigmentation after 8 weeks of usage.
In an eight week study using 2% Sepiwhite™ MSH alone, 83% of volunteers reported a more radiant complexion, 73% fewer age spots, 100% lighter age spots, and 100% more even complexion and skin tone.
In a seven day study using Sepiwhite™ MSH alone, volunteers reported hyperpigmentation was reduced by 24% and skin luminosity increased by 9%
Sepiwhite™ MSHcan be combined with a number of other ingredients designed to assist with hyperpigmentation. It can be combined with AHAs to promote a more radiant complexion and more even skin tone.
In studies using 0.2% Sepiwhite™ MSH and 2% ascorbyl glucoside, it doubled the lightening action resulting in a 13% decrease in melanin pigments.
In a two month study using Sepiwhite™ MSH alone, skin’s luminosity was increased by +1.13 L*, a measure of skin’s brightness.
Compatibility & Stability:
Excellent stability in cosmetic products with no expected color or odor changes
Compatible with formulas containing AHA and kojic acid (pH below 5)
Compatible with formulas containing arbutin, hydroquinone, niacinamide, and those above pH 7
Compatible with sunscreens
Suitable for aqueous, hydroalcoholic, or hydroglycolic formulas
Suitable for clear, colorless formulas
SEPIWHITE™ MSH Formulation Guidance
1. It’s recommended to add SEPIWHITE™ MSH into hot water phase and use weak
base like TEA, Tromethamine or AMP to neutralize it to pH 7.
The dosage of base:
pH ~ 7
Weak Base TEA Tromethamine AMP
1g SEPIWHITE MSH 0.5 g 0.4 g 0.3 g
2. It is advisable to adjust the pH of formulas containing SEPIWHITE™ MSH at the
start of formulation, by incorporating the required quantity of neutralizing agent
in the aqueous phase before emulsification.
3. Neutralizing SEPIWHITE™ MSH produces electrolytes likely to cause
fluidification. It’s recommended to use electrolyte-resistant polymers like
SEPIPLUS™ 400, SEPINOV™ EMT 10 or SEPIMAX™ ZEN.
4. Advices in different systems：
In Water solutions or Cream-gels, if using 0.5~1% SEPIWHITE™ MSH, we advise
to add 0.5 to 1 % Polysorbate 20 and adjust final pH ≥ 6.8 to prevent SEPIWHITE
MSH™ crystallization in the formula.
In emulsions, there are 2 cases as below:
1) Final pH is between 5~6.8：there are 2 solutions as below:
a). It’s recommended to add some oils as below to help its solubility.
Ratio is Oil: SEPIWHITE™ MSH ≥ 5：1.
Add SEPIWHITE™ MSH in the oily phase together with one of the 4
recommended oils and add base in the aqueous phase. Do hot process
Name of Oil Trade Name
Octyldodecanol Eutanol G
Propylene Glycol Isostearate Prisorine 2034
Ethylhexyl Methoxycinnamat Eusolex 2292
2-phenylethyl benzoate X-Tend 226
b). Solubilize 1g SEPIWHITE™ MSH into 10g ethanol and then add it into
the formula after emulsification.
2) Final pH < 5 or pH ≥6.8：Add SEPIWHITE™ MSH and base into hot water
phase (adjust pH ~7) before emulsification.
SEPIWHITE MSH – By Seppic
₹1,500.00 – ₹27,500.00
INCI: Undecylenoyl Phenylalanine
Properties:
Specificities:
Applications:
Sepiwhite™ MSH is a lipoaminoacid or vectorized essential amino acid developed from phenylalanine, an amino acid involved in melanin synthesis. MSH is an alpha-melanocyte-stimulating hormone (MSH) receptor agonist developed from this amino acid that inhibits the process of melanin synthesis from the hypothalamus to produce a reduction in melanic pigments in skin cells.
In two studies, 1% Sepiwhite™ MSH was combined with 5% niacinamide in lotion. Volunteers reported a reduction in hyperpigmentation after 8 weeks of usage.
Sepiwhite™ MSHcan be combined with a number of other ingredients designed to assist with hyperpigmentation. It can be combined with AHAs to promote a more radiant complexion and more even skin tone.
Compatibility & Stability:
SEPIWHITE™ MSH Formulation Guidance
1. It’s recommended to add SEPIWHITE™ MSH into hot water phase and use weak
base like TEA, Tromethamine or AMP to neutralize it to pH 7.
The dosage of base:
pH ~ 7
Weak Base TEA Tromethamine AMP
1g SEPIWHITE MSH 0.5 g 0.4 g 0.3 g
2. It is advisable to adjust the pH of formulas containing SEPIWHITE™ MSH at the
start of formulation, by incorporating the required quantity of neutralizing agent
in the aqueous phase before emulsification.
3. Neutralizing SEPIWHITE™ MSH produces electrolytes likely to cause
fluidification. It’s recommended to use electrolyte-resistant polymers like
SEPIPLUS™ 400, SEPINOV™ EMT 10 or SEPIMAX™ ZEN.
4. Advices in different systems：
In Water solutions or Cream-gels, if using 0.5~1% SEPIWHITE™ MSH, we advise
to add 0.5 to 1 % Polysorbate 20 and adjust final pH ≥ 6.8 to prevent SEPIWHITE
MSH™ crystallization in the formula.
In emulsions, there are 2 cases as below:
1) Final pH is between 5~6.8：there are 2 solutions as below:
a). It’s recommended to add some oils as below to help its solubility.
Ratio is Oil: SEPIWHITE™ MSH ≥ 5：1.
Add SEPIWHITE™ MSH in the oily phase together with one of the 4
recommended oils and add base in the aqueous phase. Do hot process
Name of Oil Trade Name
Octyldodecanol Eutanol G
Propylene Glycol Isostearate Prisorine 2034
Ethylhexyl Methoxycinnamat Eusolex 2292
2-phenylethyl benzoate X-Tend 226
b). Solubilize 1g SEPIWHITE™ MSH into 10g ethanol and then add it into
the formula after emulsification.
2) Final pH < 5 or pH ≥6.8：Add SEPIWHITE™ MSH and base into hot water
phase (adjust pH ~7) before emulsification.