Ascorbyl Tetraisopalmitate (ATIP) – Vitamin C – Oil Soluble – Stable Form – Liquid

INCI: Ascorbyl Tetraisopalmitate (ATIP)

CAS: 183476-82-6

Solubility – Oil Soluble

Typical Use Level: Add to Oil Soluble phase of the formula. Usage concentration 1-10%. For external use only.

Typical Applications: Lotions, gels, creams, sun care, after sun care, makeup, lip products, etc..

Can be used in formulas with a pH range of 3 to 6.

Should be added into the oil phase of formulations at temperatures below 80°C (176°F)

Key Uses of ATIP

• Skin Brightening & Pigmentation Control
  • Suppresses melanin production, reducing dark spots and uneven tone.
  • Clinical studies show 3% ATIP creams significantly decreased UV‑induced pigmentation.
• Anti‑Aging & Wrinkle Reduction
  • Stimulates collagen synthesis, improving elasticity.
  • Proven to reduce fine wrinkles around the eyes after 8 weeks of use.
• Antioxidant Protection
  • Neutralizes free radicals caused by UV exposure and pollution.
  • Provides photoprotection, reducing erythema and inflammation after sun exposure.
• Enhanced Stability
  • Unlike L‑ascorbic acid, ATIP resists oxidation and degradation from light, air, and heat.
  • Remains active for months in formulations, ensuring consistent results.
• Superior Skin Penetration
  • Oil‑soluble structure allows it to pass through the lipid‑rich stratum corneum.
  • Converts into active Vitamin C inside skin cells for maximum efficacy.
• Low Irritation Potential
  • Does not require acidic pH (unlike L‑ascorbic acid).
  • Safe even at 10% concentration, with no reported irritation in studies.

 

Feature	Ascorbyl Tetraisopalmitate (ATIP)	L‑Ascorbic Acid
Solubility	Oil‑soluble (lipophilic)	Water‑soluble
Stability	Highly stable, resists oxidation	Unstable, oxidizes quickly
Skin Penetration	Deep penetration via lipid layers	Limited penetration
Irritation Risk	Low, does not need low pH	High, requires pH ~3–3.5
Efficacy	Brightening, anti‑wrinkle, antioxidant	Strong antioxidant but unstable
Shelf Life	Long, remains active for months	Short, loses potency quickly